Sample Size for Identifying Differentially Expressed Genes in Microarray Experiments

@article{Wang2004SampleSF,
  title={Sample Size for Identifying Differentially Expressed Genes in Microarray Experiments},
  author={Sue-Jane Wang and James J. Chen},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2004},
  volume={11 4},
  pages={714-26}
}
Microarray technology allows simultaneous comparison of expression levels of thousands of genes under each condition. This paper concerns sample size calculation in the identification of differentially expressed genes between a control and a treated sample. In a typical experiment, only a fraction of genes (altered genes) is expected to be differentially expressed between two samples. Sample size determination depends on a number of factors including the specified significance level (alpha… CONTINUE READING
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