Sample Size and Power Calculations for Additive Interactions

@article{VanderWeele2012SampleSA,
  title={Sample Size and Power Calculations for Additive Interactions},
  author={T. VanderWeele},
  journal={Epidemiologic Methods},
  year={2012},
  volume={1},
  pages={159 - 188}
}
  • T. VanderWeele
  • Published 2012
  • Engineering, Medicine
  • Epidemiologic Methods
Abstract Interactions measured on the additive scale are more relevant than multiplicative interaction for assessing public health importance and also more closely related to notions of mechanistic synergism. Most work on sample size and power calculations for interaction have focused on the multiplicative scale. Here we derive analytic expressions for sample size and power calculations for interactions on the additive scale. We give formulae for detecting additive interaction on the risk scale… Expand

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