Samarium-promoted coupling of 1,10-phenanthroline with carbonyl compounds for synthesis of new ligands.

@article{Weitgenant2004SamariumpromotedCO,
  title={Samarium-promoted coupling of 1,10-phenanthroline with carbonyl compounds for synthesis of new ligands.},
  author={Jeremy A Weitgenant and Jonathan D Mortison and David J O'Neill and Brendan P. Mowery and Anders Puranen and Paul Helquist},
  journal={The Journal of organic chemistry},
  year={2004},
  volume={69 8},
  pages={2809-15}
}
1,10-Phenanthroline reacts with aldehydes and ketones in the presence of samarium diiodide to produce 2-(1-hydroxyalkyl)-1,10-phenanthrolines. The hydroxyalkyl substituent can be functionalized in numerous ways or removed to permit further ligand variation. The carbonyl coupling reaction can also be repeated to provide 2,9-disubstituted phenanthrolines. Taken together, these operations provide ready access to a large number of phenanthroline derivatives to serve as ligand libraries for catalyst… CONTINUE READING