Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats.

@article{Killinger2010SalvinorinAF,
  title={Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats.},
  author={Bryan A. Killinger and Mary Melissa Peet and Lisa E. Baker},
  journal={Pharmacology, biochemistry, and behavior},
  year={2010},
  volume={96 3},
  pages={260-5}
}
Salvia divinorum is a small perennial shrub that has gained recent popularity among the drug-using subculture as a legal alternative to hallucinogens. Salvinorin A, the main active compound found in the S.divinorum plant, is an atypical hallucinogen with pharmacological selectivity at kappa opioid (KOP) receptor sites and is a unique non-nitrogenous neoclerodane diterpene which is structurally distinct from other opioid compounds. The novel structure of salvinorin A and its specific binding… CONTINUE READING

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