Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

  title={Salvinorin A: A potent naturally occurring nonnitrogenous $\kappa$ opioid selective agonist},
  author={Bryan L. Roth and Karen Baner and Richard B. Westkaemper and Daniel J. Siebert and Kenner C. Rice and SeAnna Steinberg and Paul R Ernsberger and Richard B. Rothman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={11934 - 11939}
  • B. Roth, K. Baner, R. Rothman
  • Published 21 August 2002
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A, is a hallucinogenic plant in the mint family that has been used in traditional spiritual practices for its psychoactive properties by the Mazatecs of Oaxaca, Mexico. More recently, S. divinorum extracts and Salvinorin A have become more widely used in the U.S. as legal hallucinogens. We discovered that Salvinorin A potently and selectively inhibited 3H-bremazocine binding to cloned κ opioid receptors… 

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