Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious κ-Opioid Receptor Agonist: Structural and Functional Considerations

@article{Chavkin2004SalvinorinAA,
  title={Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious $\kappa$-Opioid Receptor Agonist: Structural and Functional Considerations},
  author={Charles Chavkin and S. P. Sud and Wenzhen Jin and Jeremy Stewart and Jordan K Zjawiony and Daniel J. Siebert and Beth Ann Toth and Sandra J. Hufeisen and Bryan L. Roth},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={308},
  pages={1197 - 1203}
}
  • C. Chavkin, S. Sud, B. Roth
  • Published 1 March 2004
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
The diterpene salvinorin A from Salvia divinorum has recently been reported to be a high-affinity and selective κ-opioid receptor agonist (Roth et al., 2002). Salvinorin A and selected derivatives were found to be potent and efficacious agonists in several measures of agonist activity using cloned human κ-opioid receptors expressed in human embryonic kidney-293 cells. Thus, salvinorin A, salvinorinyl-2-propionate, and salvinorinyl-2-heptanoate were found to be either full (salvinorin A) or… 

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