Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.

@article{Lin2015SalvianolicAB,
  title={Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.},
  author={Musen Lin and Xiaohan Zhai and Guangzhi Wang and Xiaofeng Tian and Dongyan Gao and Lei Shi and Hang Wu and Qing Fan and Jinyong Peng and Kexin Liu and Jihong Yao},
  journal={Journal of pharmacological sciences},
  year={2015},
  volume={127 2},
  pages={203-10}
}
Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia miltiorrhiza, has well-known antioxidant and anti-inflammatory actions. We aimed to evaluate the ability of SalB to protect against APAP-induced acute hepatotoxicity by inducing nuclear factor-erythroid-2-related factor 2 (Nrf2) expression. SalB… CONTINUE READING
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