Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS

@inproceedings{Yang2012SalvianolicAA,
  title={Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS},
  author={Luan-luan Yang and Dongye Li and Yan-bin Zhang and Man-yi Zhu and Dan Chen and Tong-da Xu},
  booktitle={Acta Pharmacologica Sinica},
  year={2012}
}
Aim:To investigate the action of salvianolic acid A (SalA) on angiotensin II (Ang II)-induced proliferation of human umbilical vein endothelial cells (HUVECs) and the possible signaling pathways mediating this action.Methods:Cell proliferation was examined with MTT assay. The expression levels of Src phosphorylation (phospho-Src), Akt phosphorylation (phospho-Akt), and NADPH oxidase 4 (Nox4) in HUVECs were determined by Western blot. The production of reactive oxygen species (ROS) was estimated… CONTINUE READING
9 Citations
42 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardio myocytes following ischemia/reperfusion injury

  • HJ Pan, DY Li, F Fang, D Chen, L Qi, TD Xu
  • J Cardiovasc Pharmacol
  • 2011

endothelial cells

  • VV Shuvaev, M Christofidou-Solomidou, F Bhora, K Laude, H Cai
  • J Cardiovasc Pharmacol
  • 2010

Similar Papers

Loading similar papers…