Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities

@article{Joe2012SalvianolicAB,
  title={Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities},
  author={Yeonsoo Joe and Min Zheng and Hyo Jeong Kim and Sena Kim and Md. Jamal Uddin and Chul Park and Do-gon Ryu and Shin Sung Kang and Sungwoo Ryoo and Stefan W Ryter and Ki Churl Chang and Hun-taeg Chung},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2012},
  volume={341},
  pages={850 - 858}
}
Salvia miltiorrhiza (Danshen), a traditional Chinese herbal medicine, is commonly used for the prevention and treatment of cardiovascular disorders including atherosclerosis. However, the mechanisms responsible for the vasoprotective effects of Danshen remain largely unknown. Salvianolic acid B (Sal B) represents one of the most bioactive compounds that can be extracted from the water-soluble fraction of Danshen. We investigated the effects of Danshen and Sal B on the inflammatory response in… 
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Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence
TLDR
It is demonstrated that salvianolic acid can exert cardioprotection through promoting angiogenesis in animal models of myocardial infarction.
A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of nuclear factor κB (NFκB) pathway.
Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways.
TLDR
The present results suggest that dihydromyricetin exerts its topical anti-inflammatory action through suppressing the activation of NF-κB and the phosphorylation of p38 and JNK and may be a potentially useful therapeutic agent for inflammatory-related diseases.
Treatment with salvianolic acid B restores endothelial function in angiotensin II‐induced hypertensive mice
Role of heme oxygenase-1 expression by dietary phytoconstituents: A nutritional cytoprotective strategy for human diseases
TLDR
Investigation of the role of the cytoprotective enzyme heme oxygenase-1 in human diseases and strategies for its clinical use indicate that HO-1 may functions as a potential therapeutic target in various human diseases.
Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway
TLDR
It is demonstrated that MLB inhibits NF-κB activation through PKC- and PI3K/Akt-mediated Nrf2 activation in HMEC-1 cells and protects against LPS-induced endothelial dysfunction in murine model of acute inflammation.
Involvement of heme oxygenase-1 induction in anti-vascular inflammation effects of Xanthoceras sorbifolia in human umbilical vein endothelial cells
Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression
TLDR
The therapeutic role of HO-1 in obesity, hypertension, atherosclerosis, Parkinson’s disease and hepatic fibrosis is discussed, and an updated, comprehensive list of natural HO- 1 inducers in foodstuff and medicinal herbs categorized by their chemical structures is provided.
Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components
TLDR
This paper reviews the recent findings regarding the mechanisms underlying the pharmacological actions of the active components of S miltiorrhiza depside salt, based on published works and the authors' own observations.
Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling
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References

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Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling
TLDR
These findings provide the first evidence that H2O2 induces r CMECs apoptosis via the PI3K/MEK/ERK pathway and that Sal B protects rCMECs against H 2O2-induced apoptosis through the PI 3K/Akt/Raf/MEk/ ERK pathway.
Piceatannol-3'-O-β-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity
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PG as an arginase inhibitor represents a novel molecule for the therapy of cardiovascular diseases derived from endothelial dysfunction and may be used for the design of pharmaceutical compounds.
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TLDR
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TLDR
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TLDR
It is suggested that salvianolic acids could improve rCBF in the ischemic hemisphere and inhibit platelet aggregation in rats and in vitro and in vivo.
Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats.
TLDR
Sal B showed a protective action against the ischemia-reperfusion induced injury in rat brain by reducing lipid peroxides, scavenging free radicals and improving the energy metabolism.
Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide.
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