Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo‐controlled trial

@article{Akhondzadeh2003SalviaOE,
  title={Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo‐controlled trial},
  author={Shahin Akhondzadeh and Maryam Noroozian and Mohammad Reza Mohammadi and S Ohadinia and Amirhossein Jamshidi and Mousa Khani},
  journal={Journal of Clinical Pharmacy and Therapeutics},
  year={2003},
  volume={28}
}
Background:  Alzheimer's disease is characterized by a slow, progressive decline in cognitive function and behaviour. Acetylcholine esterase inhibitors are the only agents approved by the Food and Drug Administration for the treatment of Alzheimer's disease. All other agents prescribed for the treatment of Alzheimer's disease are used on an off‐label basis. Current research into new drugs is focused on agents that will prevent, slow down and/or halt the progress of the disease process. Savia… 
View on Wiley
tahomaclinic.com
310 Citations
Highly Influential Citations
12
Background Citations
92
Methods Citations
16
Results Citations
6

310 Citations

Does herbal medicine have an effect on the cognitive function of patients with mild to moderate Alzheimer’s disease over the age of 50?
TLDR
Results of the three studies demonstrate that herbal medicine is an effective treatment in individuals over the age of 50 for the cognitive improvement of mild to moderate Alzheimer’s disease.
Alzheimer's: Phytotherapy and the most important herbs in the treatment of Alzheimer's
TLDR
Medicinal herbs can be used in the treatment of Alzheimer’s and they can be produced in the future as effective natural anti-Alzheimer's drugs.
From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors.
TLDR
The role of possible AChE inhibitors (AChEI) present in plants traditionally used in European medicine for improving memory are reviewed to point to the role of these plants as potential sources for the development of therapeutic agents for AD.
The Use of Herbal Medicine in Alzheimer's Disease—A Systematic Review
TLDR
A systematic review identified two herbs and herbal formulations with therapeutic effects for the treatment of AD and five herbs and formulations useful for cognitive impairment of AD, which have demonstrated good therapeutic effectiveness but results need to be compared with those of traditional drugs.
Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial
Role of Medicinal Plants in the Treatment of Alzheimer ’ s Disease : A Review
TLDR
Herbal remedies for AD have become more and more popular in the recent years and not without a reason that there is a possibility to slow down the brain’s degeneration caused by AD with natural treatments and it has drawn the attention of the scientific community.
Effects of medicinal plants on Alzheimer's disease and memory deficits
TLDR
The role of different medicinal plants that play an important role in the treatment of Alzheimer's disease and memory deficits using conventional herbal therapy are reviewed.
Medicinal plants for Alzheimer’s disease: An updated review
TLDR
Recent research finding regarding the efficacy of various plants according to their; cognitive enhancing, neuroprotective, antioxidant, and anti-inflammatory properties in Alzheimer’s disease will be focused on.
Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease
TLDR
The neurobiological effects of SO on the central nervous system will be reviewed, including analgesic, memory enhancing, neuroprotective, anticonvulsant, anti-addictive, sedative, anxiolytic, and skeletal muscle relaxant effects.
Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer's Disease
TLDR
The authors' review shows that S. officinalis and S. lavandulaefolia exert beneficial effects by enhancing cognitive performance both in healthy subjects and patients with dementia or cognitive impairment and is safe for this indication.
...
...

References

SHOWING 1-10 OF 27 REFERENCES
Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled trial
TLDR
Melissa officinalis extract is of value in the management of mild to moderate Alzheimer’s disease and has a positive effect on agitation in such patients and has been found to produce a significantly better outcome on cognitive function than placebo.
Medicinal Plants and Alzheimer's Disease: from Ethnobotany to Phytotherapy **
TLDR
The value of an integrative traditional and modern scientific approach to developing new treatments for dementia, but also in the understanding of disease mechanisms, is considered.
Medicinal plants and Alzheimer's disease: Integrating ethnobotanical and contemporary scientific evidence.
TLDR
The value of an integrative traditional and modern scientific approach to developing new treatments for dementia, but also in the understanding of disease mechanisms is considered.
The cholinergic hypothesis of Alzheimer’s disease: a review of progress
TLDR
The existing scientific applicability of the original cholinergic hypothesis of Alzheimer’s disease is examined by describing the biochemical and histopathological changes of neurotransmitter markers that occur in the brains of patients with Alzheimer's disease both at postmortem and neurosurgical cerebral biopsy and the behavioural consequences of cholinomimetic drugs andCholinergic lesions.
Cholinesterase inhibitor therapy stabilizes symptoms of Alzheimer disease.
  • E. Giacobini
  • Biology, Medicine
    Alzheimer disease and associated disorders
  • 2000
TLDR
It is concluded that several of these compounds have shown significant clinical efficacy and safety in the treatment of Alzheimer disease and the combination of cholinesterase inhibitors with estrogens, antioxidants, and anti-inflammatories may represent a further improvement of the therapy.
New drugs for Alzheimer's disease and other dementias
  • R. Bullock
  • Medicine, Psychology
    British Journal of Psychiatry
  • 2002
TLDR
There is good evidence to support the use of cholinesterase inhibitors, and perhaps vitamin E, and Oestrogen and anti-inflammatory agents show possibility, but there is not enough evidence tosupport routine use.
Alzheimer's disease: pathophysiology and pharmacotherapy.
TLDR
Clinically, appropriate management of AD patients with antioxidants, acetylcholinesterase inhibitors (AChEIs) and psychotropic agents can slow the progression of the disease, improve cognition, and reduce behavioral disturbances, which may enhance patient and caregiver quality-of-life and delay nursing home residence.
Therapeutic targets in the biology of Alzheimer's disease
TLDR
A new alternative has recently emerged employing small metal complexing agents that inhibit the neurotoxic hydrogen peroxide produced by β-amyloid, and which facilitate the dissolution of brain amyloid deposits in vivo in transgenic mice.
Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm)
CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory.
...
...