Salvia divinorum and salvinorin A: new pharmacologic findings.

  title={Salvia divinorum and salvinorin A: new pharmacologic findings.},
  author={Daniel J. Siebert},
  journal={Journal of ethnopharmacology},
  volume={43 1},
  • D. Siebert
  • Published 1 June 1994
  • Medicine
  • Journal of ethnopharmacology

The chemistry of Salvia divinorum

Salvinorin A (1a), a neoclerodane diterpenoid isolated from the plant, is a potent, selective agonist at the κ opioid receptor (KOR), and is the first non-nitrogenous opioid.

Salvinorin C, a new neoclerodane diterpene from a bioactive fraction of the hallucinogenic Mexican mint Salvia divinorum.

Its structure was elucidated on the basis of extensive proton and C-13 NMR experiments, as well as by comparison of the NMR data with those of the mono- and diacetate derivatives 5-7 of the major NaBH(4)-reduction product of salvinorin A (2).

Psychopharmacology of the hallucinogenic sage Salvia divinorum.

Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A.

Salvia divinorum is a vision-inducing mint used by the Mazatec people of Oaxaca, Mexico. It is grown in California and other parts of the United States where it is employed as a legal hallucinogen.

Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues.

Further modification of salvinorin A (1a), the major active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity.

Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis‐induced hypermotility: cross‐talk between κ‐opioid and cannabinoid CB1 receptors

Because intestinal inflammation upregulates cannabinoid receptors and endogenous cannabinoids, the possible involvement of the endogenous cannabinoid system in salvinorin A‐induced delay in motility in the inflamed gut is investigated.

The Use of Salvia divinorum from a Mazatec Perspective

This chapter will try to clarify the best ways to use Salvia divinorum for medicinal, psychotherapeutic, and inner exploration purposes.

Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects

The aim of this work is to comprehensively review and discuss the toxicokinetics and toxicodynamics of S. divinorum and salvinorin A, highlighting their psychological, physiological, and toxic effects.

Cytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum.

This is the first work focused on the in vitro toxicity of S. divinorum and salvinorin A using a variety of cell lines, which are extensively described in literature and have been widely used in several in vitro studies.



Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.).

Salvinorin, a new trans-neoclerodane diterpene from Salvia divinorum(Labiatae)

Salvinorin, isolated from Salvia divinorum, has been shown by spectroscopic and X-ray-crystallographic methods to be a trans-neoclerodane diterpene of structure (1). Crystals of compound (1) are

Notes on the Present Status of Ololiuhqui and the Other Hallucinogens of Mexico

  • R. Wasson
  • Linguistics
    Botanical Museum leaflets, Harvard University
  • 1963
Picietl, peyotl, teonanacatl, and ololiuhqui these were the four great divinatory plants of Mexico at the time of the Conquest. We give the names in Nahuatl, the lingua franca of that time, spoken as

A New Mexican Psychotropic Drug from the Mint Family

  • R. Wasson
  • Psychology
    Botanical Museum leaflets, Harvard University
  • 1962

0963) Notes on the present status of ololuiqui and the other hallucinogens of Mexico

  • Botanical Museum Leaflets, Harvard University

Ethnophar - macology of Ska Maria Pastora ( Salvia divinorum Epling and JativaM . )

  • Journal of Ethnopharmacology
  • 1983

Studies of Salvia divinorum (Lamiacea¢), an hallucinogenic mint from the Sierra Mazateca in

  • Economic Botany
  • 1987

Labiatae). Journal of the Chemical Society, Perkin Transactions I: Organic and Bio-Organic Chemistry

  • 1983