Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor.

@article{YanagisawaMiwa1992SalvageOI,
  title={Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor.},
  author={A Yanagisawa-Miwa and Yasuto Uchida and Fumitaka Nakamura and Takuya Tomaru and Hiroko Kido and Tomoyuki Kamijo and Taro Sugimoto and Keisuke Kaji and Masanori Utsuyama and Chieri Kurashima},
  journal={Science},
  year={1992},
  volume={257 5075},
  pages={1401-3}
}
Coronary collateral vessels reduce damage to ischemic myocardium after coronary obstruction. Factors that stimulate collateral formation are expected to have ameliorating effects on myocardial infarction. In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced infarct size. Treatment with bFGF increased the number of arterioles and capillaries in the infarct. Thus, the angiogenic action of… CONTINUE READING