Salvage abdominoperineal resection after failed Nigro protocol: modest success, major morbidity.

@article{Papaconstantinou2006SalvageAR,
  title={Salvage abdominoperineal resection after failed Nigro protocol: modest success, major morbidity.},
  author={Harry Troy Papaconstantinou and Kelli M. Bullard and David A. Rothenberger and Robert D. Madoff},
  journal={Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland},
  year={2006},
  volume={8 2},
  pages={124-9}
}
OBJECTIVE Chemotherapy and radiation (C-XRT) is the first-line therapy for epidermoid carcinomas of the anal canal (ECAC). Treatment failure occurs in up to 33% of patients. Salvage-abdominoperineal resection (APR) is the treatment of choice for locoregional failure but pre-operative radiation may increase wound complications. The purpose of this study was to evaluate patient survival and wound complications after salvage-APR for C-XRT failure. METHODS We reviewed the clinical records of all… CONTINUE READING
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