Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.

@article{Wang2015SalvadorWartsHippoPI,
  title={Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.},
  author={Lan-Hsin Wang and Nicholas E Baker},
  journal={Developmental cell},
  year={2015},
  volume={32 2},
  pages={
          191-202
        }
}
The E proteins and Id proteins are, respectively, the positive and negative heterodimer partners for the basic-helix-loop-helix protein family and as such contribute to a remarkably large number of cell-fate decisions. E proteins and Id proteins also function to inhibit or promote cell proliferation and cancer. Using a genetic modifier screen in Drosophila, we show that the Id protein Extramacrochaetae enables growth by suppressing activation of the Salvador-Warts-Hippo pathway of tumor… CONTINUE READING
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