Salt tolerant membrane adsorbers for robust impurity clearance.

  title={Salt tolerant membrane adsorbers for robust impurity clearance.},
  author={William T Riordan and Steven M. Heilmann and Kurt A. Brorson and Kannan Seshadri and Mark Raymond Etzel},
  journal={Biotechnology progress},
  volume={25 6},
Clearance of impurities such as viruses, host cell protein (HCP), and DNA is a critical purification design consideration for manufacture of monoclonal antibody therapeutics. Anion exchange chromatography has frequently been utilized to accomplish this goal; however, anion exchange adsorbents based on the traditional quaternary amine (Q) ligand are… CONTINUE READING