Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan.

@article{Melo1999SaltsensitiveHI,
  title={Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan.},
  author={Luis Gabriel Melo and Anthony T. Veress and Chee K Chong and Uwe Ackermann and Harald Sonnenberg},
  journal={The American journal of physiology},
  year={1999},
  volume={277 3 Pt 2},
  pages={R624-30}
}
Mice harboring a functional deletion of the pro-atrial natriuretic peptide (ANP) gene (-/-) develop salt-sensitive hypertension relative to their wild-type (+/+) counterparts after prolonged (>1 wk) maintenance on high-salt (HS, 8% NaCl) diet. We reported recently that the sensitization of arterial blood pressure (ABP) to dietary salt in the -/- mice is associated with failure to downregulate plasma renin activity. To further characterize the role and mechanism of ANG II in the sensitization of… CONTINUE READING