Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.

@article{Shi2008SaltsensitiveHA,
  title={Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.},
  author={Peijun P Shi and X Renee Cao and Eileen M Sweezer and Thomas S Kinney and Nathan Rhys Williams and Russell F. Husted and Ramesh Nair and Robert M. Weiss and R Anthony Williamson and Curt D. Sigmund and Peter M. Snyder and Olivier Staub and John B. Stokes and Baoli Yang},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={295 2},
  pages={F462-70}
}
Nedd4-2 has been proposed to play a critical role in regulating epithelial Na+ channel (ENaC) activity. Biochemical and overexpression experiments suggest that Nedd4-2 binds to the PY motifs of ENaC subunits via its WW domains, ubiquitinates them, and decreases their expression on the apical membrane. Phosphorylation of Nedd4-2 (for example by Sgk1) may regulate its binding to ENaC, and thus ENaC ubiquitination. These results suggest that the interaction between Nedd4-2 and ENaC may play a… CONTINUE READING
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