Salt-sensitive hypertension, Na+/Ca2+ exchanger, and vascular smooth muscle.

  title={Salt-sensitive hypertension, Na+/Ca2+ exchanger, and vascular smooth muscle.},
  author={Takahiro Iwamoto and Satomi Kita and Takeshi Katsuragi},
  journal={Trends in cardiovascular medicine},
  volume={15 8},
Hypertension is the most common chronic disease and is the leading risk factor for death caused by stroke, myocardial infarction, and end-stage renal failure. The critical importance of excess salt intake in the pathogenesis of hypertension is widely recognized. However, the molecular mechanisms underlying salt-sensitive hypertension remain obscure. Recent studies using selective Na(+)/Ca(2+) exchanger (NCX) inhibitors and genetically engineered mice provide compelling evidence that salt… CONTINUE READING
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