Salt overload damages the glycocalyx sodium barrier of vascular endothelium

@inproceedings{Oberleithner2011SaltOD,
  title={Salt overload damages the glycocalyx sodium barrier of vascular endothelium},
  author={Hans Oberleithner and Wladimir Peters and Kristina Kusche-Vihrog and Stefanie Korte and Hermann Schillers and Katrin Kliche and Kilian Oberleithner},
  booktitle={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2011}
}
Sodium overload stiffens vascular endothelial cells in vitro and promotes arterial hypertension in vivo. The hypothesis was tested that the endothelial glycocalyx (eGC), a mesh of anionic biopolymers covering the surface of the endothelium, participates in the stiffening process. By using a mechanical nanosensor, mounted on an atomic force microscope, height (∼400 nm) and stiffness (∼0.25 pN/nm) of the eGC on the luminal endothelial surface of split-open human umbilical arteries were quantified… CONTINUE READING