Salt or sugar for your injured brain? A meta-analysis of randomised controlled trials of mannitol versus hypertonic sodium solutions to manage raised intracranial pressure in traumatic brain injury.

@article{Rickard2014SaltOS,
  title={Salt or sugar for your injured brain? A meta-analysis of randomised controlled trials of mannitol versus hypertonic sodium solutions to manage raised intracranial pressure in traumatic brain injury.},
  author={Annette C Rickard and Jason E Smith and Philip B. Newell and Alexander Bailey and Anthony Kehoe and Clifford Mann},
  journal={Emergency medicine journal : EMJ},
  year={2014},
  volume={31 8},
  pages={
          679-83
        }
}
BACKGROUND Rising intracranial pressure (ICP) is a poor prognostic indicator in traumatic brain injury (TBI). Both mannitol and hypertonic sodium solutions are used to treat raised ICP in patients with TBI. OBJECTIVE This meta-analysis compares the use of mannitol versus hypertonic sodium solutions for ICP control in patients with TBI. DATA SOURCES AND STUDY ELIGIBILITY Randomised clinical trials in adults with TBI and evidence of raised ICP, which compare the effect on ICP of hypertonic… CONTINUE READING

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