Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene.

Abstract

AIM The basolateral chloride channel ClC-Kb facilitates Cl reabsorption in the distal nephron of the human kidney. Functional mutations in CLCNKB are associated with Bartter's syndrome type 3, a hereditary salt-losing nephropathy. To address the function of ClC-K2 in vivo, we generated ClC-K2-deficient mice. METHODS ClC-K2-deficient mice were generated… (More)
DOI: 10.1111/apha.12755

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@article{Grill2016SaltlosingNI, title={Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene.}, author={Allan K Grill and Ingo Schiessl and Bernhard Gess and K Fremter and A. Hammer and Hayo Castrop}, journal={Acta physiologica}, year={2016}, volume={218 3}, pages={198-211} }