Salt intake and depletion increase circulating levels of endogenous ouabain in normal men.

@article{Manunta2006SaltIA,
  title={Salt intake and depletion increase circulating levels of endogenous ouabain in normal men.},
  author={Paolo Manunta and Bruce P. M. Hamilton and John M. Hamlyn},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={290 3},
  pages={R553-9}
}
High-salt diets elevate circulating Na+ pump inhibitors, vascular resistance, and blood pressure. Ouabain induces a form of hypertension mediated via the alpha2-Na+ pump isoform and the calcium influx mode of the vascular sodium calcium exchanger (NCX). Whereas elevated levels of an endogenous ouabain (EO) and NCX have been implicated in salt-sensitive hypertension, acute changes in sodium balance do not affect plasma EO. This study investigated the impact of longer-term alterations in sodium… CONTINUE READING
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Effects of R558 HIGH SALT INCREASES ENDOGENOUS OUABAIN AJP-Regul

  • EJ Eichorn, AL McGhie, +6 authors PA. Grayburn
  • Integr Comp Physiol
  • 2006
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