Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase.

@article{Kitiyakara2003SaltIO,
  title={Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase.},
  author={Chagriya Kitiyakara and Tina Chabrashvili and Yifan Chen and Jonathan Blau and Alex Karber and Shakil Aslam and William J. Welch and Christopher Stuart Wilcox},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 11},
  pages={2775-82}
}
The hypothesis that a high salt (HS) intake increases oxidative stress was investigated and was related to renal cortical expression of NAD(P)H oxidase and superoxide dismutase (SOD). 8-Isoprostane PGF(2alpha) and malonyldialdehyde were measured in groups (n = 6 to 8) of conscious rats during low-salt, normal-salt, or HS diets. NADPH- and NADH-stimulated superoxide anion (O(2)(.-)) generation was assessed by chemiluminescence, and expression of NAD(P)H oxidase and SOD were assessed with real… CONTINUE READING

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Despite suppression of the renin - angiotensin system , salt loading enhances oxidative stress .
Despite suppression of the renin - angiotensin system , salt loading enhances oxidative stress .
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