Salt-induced hypertension in rats alters the response of isolated aortic rings to cromakalim.

@article{Obiefuna2001SaltinducedHI,
  title={Salt-induced hypertension in rats alters the response of isolated aortic rings to cromakalim.},
  author={P. C. M. Obiefuna and Idongesit P Obiefuna},
  journal={The West Indian medical journal},
  year={2001},
  volume={50 1},
  pages={
          17-21
        }
}
The effect of cromakalim, an opener of ATP-sensitive potassium (KATP) channel, on precontracted aortic rings from control and salt-loaded rats was studied in Sprague-Dawley rats. Salt-loading experiments involved the induction of hypertension by 6-week feeding of 80 g sodium chloride (NaCl) per kilogram (kg) diet while the control diet had 3 g NaCl per kg diet. Blood pressure and heart rate were determined by cannulation of a femoral artery under urethane/alpha-chloralose anaesthesia. Isolated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS