Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition.

@article{Rudd1999SaltinducedHI,
  title={Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition.},
  author={M Audrey Rudd and Maria R. Trolliet and Susan Hope and Anne Ward Scribner and Geraldine Daumerie and George Toolan and Timothy Cloutier and Joseph Loscalzo},
  journal={The American journal of physiology},
  year={1999},
  volume={277 2 Pt 2},
  pages={H732-9}
}
Although recent evidence suggests that reduced nitric oxide (NO) production may be involved in salt-induced hypertension, the specific NO synthase (NOS) responsible for the conveyance of salt sensitivity remains unknown. To determine the role of inducible NOS (NOS II) in salt-induced hypertension, we treated Dahl salt-resistant (DR) rats with the selective NOS II inhibitor 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT) for 12 days. Tail-cuff systolic blood pressures rose 29 ± 6 and 42 ± 8… CONTINUE READING