Salt inactivates endothelial nitric oxide synthase in endothelial cells.

  title={Salt inactivates endothelial nitric oxide synthase in endothelial cells.},
  author={Juan Jenny Li and James White and Ling Guo and Xiaomin Zhao and Jia-fu Wang and Eric J. Smart and Xiang-an Li},
  journal={The Journal of nutrition},
  volume={139 3},
There is a 1-4 mmol/L rise in plasma sodium concentrations in individuals with high salt intake and in patients with essential hypertension. In this study, we used 3 independent assays to determine whether such a small increase in sodium concentrations per se alters endothelial nitric oxide synthase (eNOS) function and contributes to hypertension. By directly measuring NOS activity in living bovine aortic endothelial cells, we demonstrated that a 5-mmol/L increase in salt concentration (from… CONTINUE READING


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Plasma sodium stiffens vascular endothelium and reduces nitric oxide release.

Proceedings of the National Academy of Sciences of the United States of America • 2007
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