Salt and the newborn kidney

  title={Salt and the newborn kidney},
  author={George B. Haycock and Anita C. Aperia},
  journal={Pediatric Nephrology},
Renal function differs in term infants from that in adults, with lower glomerular filtration rate (GFR) and reduced proximal tubular reabsorption of sodium (Na) and water: nevertheless, it is adequate for their needs. This is not true of very preterm infants in whom hyponatraemia is common. Animal studies have shown that Na+, K+-ATPase and the Na+/K+ exchanger are poorly expressed at birth with rapid postnatal rises. Cell receptors for hormones that influence tubular Na transport are less… CONTINUE READING
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