Salt Potentiates Methylamine Counteraction System to Offset the Deleterious Effects of Urea on Protein Stability and Function

@inproceedings{Rahman2015SaltPM,
  title={Salt Potentiates Methylamine Counteraction System to Offset the Deleterious Effects of Urea on Protein Stability and Function},
  author={Safikur Rahman and Md. Tabish Rehman and Laishram Rajendrakumar Singh and Marina Warepam and Faizan Ahmad and Tanveer Ali Dar},
  booktitle={PloS one},
  year={2015}
}
Cellular methylamines are osmolytes (low molecular weight organic compounds) believed to offset the urea's harmful effects on the stability and function of proteins in mammalian kidney and marine invertebrates. Although urea and methylamines are found at 2:1 molar ratio in tissues, their opposing effects on protein structure and function have been questioned on several grounds including failure to counteraction or partial counteraction. Here we investigated the possible involvement of cellular… CONTINUE READING

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