Salsolinol Facilitates Glutamatergic Transmission to Dopamine Neurons in the Posterior Ventral Tegmental Area of Rats

@inproceedings{Xie2012SalsolinolFG,
  title={Salsolinol Facilitates Glutamatergic Transmission to Dopamine Neurons in the Posterior Ventral Tegmental Area of Rats},
  author={Guiqin Xie and Jiang-hong Ye},
  booktitle={PloS one},
  year={2012}
}
Although in vivo evidence indicates that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse, the underlying mechanisms have not been fully elucidated. We have reported previously that salsolinol stimulates dopamine neurons in the posterior ventral tegmental area (p-VTA) partly by reducing inhibitory GABAergic transmission, and that ethanol increases glutamatergic transmission to VTA-dopamine neurons via the activation of… CONTINUE READING
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Salsolinol stimulates dopamine neurons in slices of posterior VTA indirectly by activating mu-opioid receptors

  • G Xie, L Hipolito, W Zuo, A Polache, L Granero
  • J Pharmacol Exp Ther
  • 2011
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