Salsalate Activates Brown Adipose Tissue in Mice

@article{vanDam2014SalsalateAB,
  title={Salsalate Activates Brown Adipose Tissue in Mice},
  author={Andrea D. van Dam and Kimberly J. Nahon and Sander Kooijman and Susan M van den Berg and Anish A. Kanhai and Takuya Kikuchi and Mattijs M. Heemskerk and Vanessa van Harmelen and Marc Lomb{\`e}s and Anita M van den Hoek and Menno P. J. de Winther and Esther Lutgens and Bruno Guigas and Patrick C. N. Rensen and Mari{\"e}tte R Boon},
  journal={Diabetes},
  year={2014},
  volume={64},
  pages={1544 - 1554}
}
Salsalate improves glucose intolerance and dyslipidemia in type 2 diabetes patients, but the mechanism is still unknown. The aim of the current study was to unravel the molecular mechanisms involved in these beneficial metabolic effects of salsalate by treating mice with salsalate during and after development of high-fat diet–induced obesity. We found that salsalate attenuated and reversed high-fat diet–induced weight gain, in particular fat mass accumulation, improved glucose tolerance, and… Expand
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