Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation.

@article{Finch2006SalpingooophorectomyAT,
  title={Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation.},
  author={Amy P M Finch and Mario E. Beiner and Jan A. Lubiński and Henry T. Lynch and Pal Moller and Barry Rosen and Joan Zugay Murphy and Parviz Ghadirian and Eitan Friedman and William D Foulkes and C Kim-sing and Teresa Wagner and Nadine Tung and Fergus J. Couch and Dominique Stoppa-Lyonnet and Peter J. Ainsworth and Mary Daly and Babara Pasini and Ruth Gershoni-baruch and Charis Eng and Olufunmilayo I. Olopade and Jane L McLennan and Beth Y. Karlan and Jeffrey N. Weitzel and Ping Sun and Steven A Narod},
  journal={JAMA},
  year={2006},
  volume={296 2},
  pages={185-92}
}
CONTEXT Women with BRCA1 or BRCA2 mutation are often advised to undergo preventive oophorectomy. The effectiveness of this intervention has not been prospectively evaluated in a large cohort. OBJECTIVES To estimate the incidence of ovarian, fallopian tube, and primary peritoneal cancer in women who carry a deleterious mutation in BRCA1 or BRCA2. To estimate the reduction in risk of these cancers associated with a bilateral prophylactic salpingo-oophorectomy. DESIGN, SETTING, AND… CONTINUE READING
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