Salmonellae interplay with host cells

@article{Haraga2008SalmonellaeIW,
  title={Salmonellae interplay with host cells},
  author={Andrea Haraga and Maikke B. Ohlson and Samuel I. Miller},
  journal={Nature Reviews Microbiology},
  year={2008},
  volume={6},
  pages={53-66}
}
Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of the molecular mechanisms that underpin the interactions of salmonellae with their animal hosts has advanced greatly over the past decade, mainly through the study of Salmonella enterica serovar Typhimurium in tissue culture and animal models of infection. Knowledge of these bacterial processes and host responses has painted a dynamic and complex picture of the interaction between salmonellae and animal… 

Figures, Tables, and Topics from this paper

Salmonellae interactions with host processes
TLDR
Current knowledge of the complex interplay between bacterial and host factors that leads to inflammation, disease and, in most cases, control of the infection by its animal hosts is summarized, with a particular focus on Salmonella enterica subsp.
Salmonella Typhimurium metabolism affects virulence in the host - A mini-review.
TLDR
Which metabolic factors that are essential for Salmonella Typhimurium growth in the intestine, in cultured epithelial and macrophage-like cell lines, at systemic sites during invasive salmonellosis, and during long term asymptomatic colonization of the host are highlighted.
Exploiting host immunity: the Salmonella paradigm.
TLDR
Recent findings on the mechanisms by which Salmonella establishes systemic and chronic infection, including strategies involving manipulation of innate immune signaling and inflammatory forms of cell death, as well as immune evasion by establishing residency in M2 macrophages are reviewed.
Understanding the complexities of Salmonella–host crosstalk as revealed by in vivo model organisms
TLDR
A compilation of various advances of ST–host interactions at cellular and molecular levels that has come from investigations involving model organisms is compiled.
Enteropathogenic Escherichia coli, Samonella, Shigella and Yersinia: cellular aspects of host-bacteria interactions in enteric diseases
TLDR
This work overviews the most important molecular strategies developed by enteropathogenic Escherichiacoli, Salmonella enterica, Shigella flexneri, and Yersinia enterocolitica to cause enteric infections.
Spread of Salmonella enterica in the body during systemic infection: unravelling host and pathogen determinants
TLDR
It is highlighted how infections within host tissues are truly heterogeneous processes despite the fact that they are caused by the expansion of a genetically homogeneous microbial population, which might aid the development of novel targeted preventative measures and drug regimens.
Mechanisms of Salmonella pathogenesis in animal models
TLDR
Overall use of this modified mouse model provides a more nuanced understanding of Salmonella intestinal infection in the context of the microbiota with implications for the ability to predict human risk.
The metabolic pathways utilized by Salmonella Typhimurium during infection of host cells
TLDR
A synthesis of what has been discovered to date regarding the metabolic adaptation of S. Typhimurium to survival and growth within the infected host is offered.
Chemical genetics and immunomodulation in Salmonella enterica serovar typhimurium infection
TLDR
A new antimicrobial property of the proton pump inhibitor omeprazole is reported, which interfered with SPI2-mediated intracellular replication of S. Typhimurium in RAW264.7 cells, which underlines the need of shifting from bulk to individual cell analysis when studying host-pathogen interactions.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 215 REFERENCES
Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells
TLDR
It is demonstrated that S. typhimurium manipulates the migratory properties of infected GI phagocytes with a type III secretion system and shows that one secreted effector, SrfH, interacts with the host protein TRIP6, a member of the zyxin family of adaptor proteins that regulate motility.
The Intracellular Fate of Salmonella Depends on the Recruitment of Kinesin
TLDR
Bacterial effector proteins translocated into the host cell by a type III secretion system antagonistically regulated this event and SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics.
A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells.
TLDR
A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intrACEllular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte.
Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine
TLDR
It is demonstrated that SPI-2 expression precedes penetration of the intestinal epithelium and may be involved in preparing Salmonella to successfully resist the antimicrobial environment encountered within macrophages.
Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway1
TLDR
It is suggested that AvrA may limit virulence in vertebrates in a manner analogous to avirulence factors in plants, and is the first bacterial effector from a mammalian pathogen that has been ascribed such a function.
Role of acid tolerance response genes in Salmonella typhimurium virulence
TLDR
Data indicate that separate acid tolerance response genes may have different roles in S. typhimurium virulence, and no relevant differences in intracellular survival or invasion rates were observed for the two mutants in macrophages and epithelial cells.
Identification of a pathogenicity island required for Salmonella survival in host cells.
TLDR
The "pathogenicity island" harboring the spi genes may encode the virulence determinants that set Salmonella apart from other enteric pathogens.
Salmonella Modulates Vesicular Traffic by Altering Phosphoinositide Metabolism
TLDR
SopB, a phosphoinositide phosphatase that is delivered into host cells by a type III secretion system, was essential for the establishment of Salmonella's intracellular replicative niche and was responsible for maintaining high levels of phosphatidylinositol-three-phosphate in the membrane of the bacteria-containing vacuoles.
Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo.
TLDR
This work has recently used a variation of this method, involving mixed infections of single and double mutant strains, to study virulence gene interaction in vivo, to provide a sensitive measure of virulence attenuation referred to as the competitive index.
Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
TLDR
The expression profile identified alterations in numerous virulence and SOS response genes and revealed unexpected findings concerning the biology of the Salmonella–macrophage interaction, suggesting that intracellular growth involves novel macrophage‐associated functions.
...
1
2
3
4
5
...