Salmonella typhimurium invasion induces apoptosis in infected macrophages.

@article{Monack1996SalmonellaTI,
  title={Salmonella typhimurium invasion induces apoptosis in infected macrophages.},
  author={Denise M. Monack and B Raupach and Alexander E. Hromockyj and Stanley Falkow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 18},
  pages={
          9833-8
        }
}
  • D. Monack, B. Raupach, +1 author S. Falkow
  • Published 1996
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Invasive Salmonella typhimurium induces dramatic cytoskeletal changes on the membrane surface of mammalian epithelial cells and RAW264.7 macrophages as part of its entry mechanism. Noninvasive S. typhimurium strains are unable to induce this membrane ruffling. Invasive S. typhimurium strains invade RAW264.7 macrophages in 2 h with 7- to 10-fold higher levels than noninvasive strains. Invasive S. typhimurium and Salmonella typhi, independent of their ability to replicate intracellularly, are… Expand
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Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism.
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It is concluded that invasive S. typhimurium induces membrane ruffling and its own internalization by a rac-independent, growth factor-receptor-independent signaling pathway. Expand
Macrophage killing is an essential virulence mechanism of Salmonella typhimurium.
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It is reported that 6-14 hr after Salmonella enters the macrophage and replicates, it resides in large vacuoles and causes the destruction of these cells and this findings suggest that killing and escape from macrophages may be as important steps inSalmonella pathogenesis as are survival and replication in these host cells. Expand
Intracellular survival of wild-type Salmonella typhimurium and macrophage-sensitive mutants in diverse populations of macrophages
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It is demonstrated that survival of S. typhimurium within macrophages varies with the source of cells, with a distinct ability to survive in macrophage from mouse spleens, where S. Typhimurio grows rapidly. Expand
Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes
Infection of a murine‐spleen dendritic cell line by Listeria monocytogenes was found to induce cell death through apoptosis. To characterize the bacterial product(s) involved in induction ofExpand
Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches
TLDR
Invasion of M cells was associated with the ability of the bacteria to invade tissue culture cells, and replicating Salmonella began to enter both the apical and basolateral surfaces of enterocytes adjacent to infected M cells. Expand
Shigella flexneri induces apoptosis in infected macrophages
TLDR
This work reports on the mechanism of cytotoxicity used by S. flexneri to kill macrophages and demonstrates that other bacterial cytotoxic mechanisms do not lead to apoptosis, the first evidence that an invasive bacterial pathogen can induce suicide in its host cells. Expand
IpaB mediates macrophage apoptosis induced by Shigella flexneri
TLDR
It is demonstrated that ipaB is essential for S. flexneri to induce apoptosis in macrophages as shown by both changes in ultrastructural morphology and fragmentation of the host ceil DNA. Expand
Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria
TLDR
It is reported that ruffles elicited by invasive Salmonella directly mediate internalization of non-invasive bacteria in a macropinocytotic fashion, a phenomenon the authors term 'passive entry'. Expand
Host restriction phenotypes of Salmonella typhi and Salmonella gallinarum
TLDR
In vitro evidence suggests that S. gallinarum is taken up in murine phagocytic cells by a mechanism different from that of S. typhimurium, which causes systemic infection in the mouse and S. typhi, which is incapable of entering the murine Peyer's patch epithelium. Expand
Protein phosphorylation in murine peritoneal macrophages induced by infection with Salmonella species
TLDR
The view that phosphorylation of the 85- and 72-kDa proteins occurs in the macrophage during the early phases of the interaction between Salmonella organisms and macrophages is supported. Expand
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