Salmonella typhimurium invasion induces apoptosis in infected macrophages.

  title={Salmonella typhimurium invasion induces apoptosis in infected macrophages.},
  author={Denise M Monack and B{\"a}rbel Raupach and Alexander E. Hromockyj and Stanley Falkow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 18},
Invasive Salmonella typhimurium induces dramatic cytoskeletal changes on the membrane surface of mammalian epithelial cells and RAW264.7 macrophages as part of its entry mechanism. Noninvasive S. typhimurium strains are unable to induce this membrane ruffling. Invasive S. typhimurium strains invade RAW264.7 macrophages in 2 h with 7- to 10-fold higher levels than noninvasive strains. Invasive S. typhimurium and Salmonella typhi, independent of their ability to replicate intracellularly, are… CONTINUE READING
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