Salmonella typhimurium induces IFN-gamma production in murine splenocytes. Role of natural killer cells and macrophages.

@article{Ramarathinam1993SalmonellaTI,
  title={Salmonella typhimurium induces IFN-gamma production in murine splenocytes. Role of natural killer cells and macrophages.},
  author={L Ramarathinam and David W. Niesel and Gary R. Klimpel},
  journal={Journal of immunology},
  year={1993},
  volume={150 9},
  pages={3973-81}
}
IFN-gamma is a cytokine known to play an important role in host defense against Salmonella typhimurium. The lymphoid cells required for in vitro production of IFN-gamma after S. typhimurium stimulation of mouse spleen cells was investigated. Spleen cells depleted of cells bearing NK1.1, asialo GM1, Thy 1.2, or CD5 resulted in a significant reduction in IFN-gamma production after stimulation with S. typhimurium. In contrast, Con A-induced IFN-gamma production was only slightly reduced after… CONTINUE READING

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Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella typhimurium infections.

Proceedings of the National Academy of Sciences of the United States of America • 2013

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