Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis

@inproceedings{Diamond2017SalmonellaTI,
  title={Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis},
  author={Catherine Emma Diamond and Keith Weng Kit Leong and Maurizio Vacca and Jack Rivers-Auty and David Brough and Alessandra Mortellaro},
  booktitle={Scientific Reports},
  year={2017}
}
Large molecular complexes known as inflammasomes regulate the release of IL-1β from immune cells in response to infection and injury. Salmonella typhimurium infection is reported to activate NLRP3 and NLRC4 inflammasomes which are subsequently involved in pyroptosis of the cell and pathogen clearance. However, the response to S. typhimurium in primary human monocytes has not been studied in detail. The aim of this study was to investigate the effect of S. typhimurium on inflammasomes in primary… CONTINUE READING
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