Salmonella typhimurium histidine periplasmic permease mutations that allow transport in the absence of histidine-binding proteins.


Periplasmic transport systems consist of a membrane-bound complex and a periplasmic substrate-binding protein and are postulated to function by translocating the substrate either through a nonspecific pore or through specific binding sites located in the membrane complex. We have isolated mutants carrying mutations in one of the membrane-bound components of… (More)


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