Salmonella typhi uses CFTR to enter intestinal epithelial cells
@article{Pier1998SalmonellaTU, title={Salmonella typhi uses CFTR to enter intestinal epithelial cells}, author={G. Pier and M. Grout and T. Zaidi and G. Meluleni and S. Mueschenborn and G. Banting and R. Ratcliff and M. Evans and W. Colledge}, journal={Nature}, year={1998}, volume={393}, pages={79-82} }
Homozygous mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF. [...] Key Result Cells expressing wild-type CFTR internalized more S. typhi than isogenic cells expressing the most common CFTR mutation, a phenylalanine deleted at residue 508 (Δ508). Monoclonal antibodies and synthetic peptides containing a sequence corresponding to the first predicted extracellular domain of CFTR inhibited uptake of S. typhi.Expand Abstract
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