Salmonella typhi uses CFTR to enter intestinal epithelial cells

@article{Pier1998SalmonellaTU,
  title={Salmonella typhi uses CFTR to enter intestinal epithelial cells},
  author={Gerald B. Pier and Martha Grout and Tanweer S Zaidi and Gloria Meluleni and Simone Mueschenborn and George S Banting and Rosemary Ratcliff and Martin John Evans and William Henry Colledge},
  journal={Nature},
  year={1998},
  volume={393},
  pages={79-82}
}
Homozygous mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF. [...] Key Result Cells expressing wild-type CFTR internalized more S. typhi than isogenic cells expressing the most common CFTR mutation, a phenylalanine deleted at residue 508 (Δ508). Monoclonal antibodies and synthetic peptides containing a sequence corresponding to the first predicted extracellular domain of CFTR inhibited uptake of S. typhi.Expand
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Resistance to typhoid fever
Cystic fibrosis (CF) is the most common autosomal recessive disease of the caucasian population and is caused by mutations in the CF transmembrane conductance regulator (CFTR), a cAMP-regulated…
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Within a population of MDCK–GFP-CFTR cells, there are cells with markedly different abilities to ingest bacteria via CFTR, and overexpression of the CFTR receptor does not increase total bacterial uptake but rather allows more epithelial cells to ingest fewer total bacteria.
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TLDR
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TLDR
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Distribution of CFTR variations in an Indonesian enteric fever cohort.
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A correlation exists between variations in the CFTR gene and protection from enteric fever, and the IVS8CA polymorphism that was identified previously may be the principal functional variation causing the difference in susceptibility.
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