Salmonella typhi uses CFTR to enter intestinal epithelial cells

@article{Pier1998SalmonellaTU,
  title={Salmonella typhi uses CFTR to enter intestinal epithelial cells},
  author={G. Pier and M. Grout and T. Zaidi and G. Meluleni and S. Mueschenborn and G. Banting and R. Ratcliff and M. Evans and W. Colledge},
  journal={Nature},
  year={1998},
  volume={393},
  pages={79-82}
}
  • G. Pier, M. Grout, +6 authors W. Colledge
  • Published 1998
  • Biology, Medicine
  • Nature
  • Homozygous mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF. [...] Key Result Cells expressing wild-type CFTR internalized more S. typhi than isogenic cells expressing the most common CFTR mutation, a phenylalanine deleted at residue 508 (Δ508). Monoclonal antibodies and synthetic peptides containing a sequence corresponding to the first predicted extracellular domain of CFTR inhibited uptake of S. typhi.Expand Abstract
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