Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway.

@article{Haghjoo2004SalmonellaTE,
  title={Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway.},
  author={Erik Haghjoo and Jorge E. Gal{\'a}n},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 13},
  pages={4614-9}
}
Many bacterial pathogens encode the cytolethal distending toxin (CDT), which causes host cells to arrest during their cell cycle by inflicting DNA damage. CDT is composed of three proteins, CdtA, CdtB, and CdtC. CdtB is the enzymatically active or A subunit, which possesses DNase I-like activity, whereas CdtA and CdtC function as heteromeric B subunits that mediate the delivery of CdtB into host cells. We show here that Salmonella enterica serovar Typhi encodes CDT activity, which depends on… CONTINUE READING
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