Salmonella induces macrophage death by caspase‐1‐dependent necrosis

@article{Brennan2000SalmonellaIM,
  title={Salmonella induces macrophage death by caspase‐1‐dependent necrosis},
  author={Molly Brennan and Brad T. Cookson},
  journal={Molecular Microbiology},
  year={2000},
  volume={38}
}
We provide evidence that Salmonella typhimurium kills phagocytes by an unusual proinflammatory mechanism of necrosis that is distinguishable from apoptosis. Infection stimulated a distinctly diffuse pattern of DNA fragmentation in macrophages, which contrasted with the marked nuclear condensation displayed by control cells undergoing chemically induced apoptosis. In apoptotic cells, DNA fragmentation and nuclear condensation result from caspase‐3‐mediated proteolysis; caspases also subvert… 

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