Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation.

@article{Marchelletta2015SalmonellainducedDO,
  title={Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation.},
  author={Ronald R. Marchelletta and M{\'e}lanie G. Gareau and Sharon Okamoto and Donald G. Guiney and Kim E Barrett and Joshua Fierer},
  journal={The Journal of infectious diseases},
  year={2015},
  volume={212 1},
  pages={128-36}
}
BACKGROUND Gastroenteritis is the most common manifestation of nontyphoidal Salmonella enterica infections, but little is known about the pathogenesis of diarrhea in this infection METHODS To determine whether polymorphonuclear neutrophils (PMNs) are required for diarrhea for Salmonella colitis, we infected kanamycin-pretreated interleukin 8R (IL-8R) mutant mice and controls, both with nonmutant Slc11a1 (Nramp1, ItyR). We compared the 2 mouse strains for increases in fecal water content… CONTINUE READING