Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation.

@article{Catron2004SalmonellaES,
  title={Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation.},
  author={Drew M. Catron and Yvonne Lange and Jayme Borensztajn and Matthew D. Sylvester and Bradley D. Jones and Kasturi Haldar},
  journal={Infection and immunity},
  year={2004},
  volume={72 2},
  pages={1036-42}
}
We have previously shown that Salmonella enterica serovar Typhimurium infection perturbs the host cholesterol biosynthetic pathway. Here we show that inhibiting the first step of this pathway (3-hydroxy-3-methylglutaryl coenzyme A reductase) reduces the growth of intracellular S. enterica serovar Typhimurium and has no effect on extracellular bacterial growth. Selectively inhibiting synthesis of downstream sterol components has no effect on infection, suggesting that the effect of statins on… CONTINUE READING