Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines

@article{John2009SalmonellaDL,
  title={Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines},
  author={Ashley L St John and Soman N. Abraham},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={1259-1265}
}
We report that infection of draining lymph nodes (DLNs) by Salmonella typhimurium results in the specific downregulation of the homeostatic chemokines CCL21 and CXCL13, which are essential for normal DLN organization and function. Our data reveal that the mechanism of this suppression is dependent on S. typhimurium LPS (sLPS). The decrease in CCL21 expression involves interaction between sLPS and CCL21-producing cells within DLNs, triggering a distinct Toll-like receptor 4 (TLR4)-mediated host… CONTINUE READING

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