Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma.

@article{Berger2013SalmonellaSA,
  title={Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma.},
  author={Elisa Berger and Roc{\'i}o Soldati and Nicole Huebener and Oliver Hohn and Alexander Stermann and Tahir Durmus and Stephan Lobitz and Ana Claudia Zenclussen and Holger Christiansen and Holger N Lode and Stefan Fest},
  journal={Cancer letters},
  year={2013},
  volume={331 2},
  pages={167-73}
}
Attenuated Salmonella is an approved oral life vaccine that is currently entering pre-clinical cancer vaccination studies as a promising DNA carrier. In a syngeneic mouse model for neuroblastoma, oral gavage of Salmonella typhimurium (SL7207) carrying recent generated survivin DNA vaccines induced a stronger cellular anti-NB immune response than gene gun application or injection of lentivirally transduced bone marrow-derived DCs. The level of Salmonella-associated side effects was not… CONTINUE READING
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