Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.

  title={Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.},
  author={Peter M. A. Calverley and Julie Anne Anderson and Bartolome Celli and Gary Thomas Ferguson and Christine Jenkins and Paul W. Jones and Julie Carol Yates and Joergen Vestbo},
  journal={The New England journal of medicine},
  volume={356 8},
BACKGROUND Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown. METHODS We conducted a randomized, double-blind trial comparing salmeterol at a dose of 50 microg plus fluticasone propionate at a dose of 500 microg twice daily (combination regimen), administered with a single inhaler, with placebo, salmeterol alone, or fluticasone propionate alone for a period of 3 years. The primary… CONTINUE READING
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