Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: sparing effects of chlorogenic acid and serum albumin.

@article{Pietraforte2006SalivaryUA,
  title={Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: sparing effects of chlorogenic acid and serum albumin.},
  author={Donatella Pietraforte and M. Castelli and Alessio Metere and Giuseppe Scorza and Paola Samoggia and Antonio Menditto and Maurizio Minetti},
  journal={Free radical biology & medicine},
  year={2006},
  volume={41 12},
  pages={1753-63}
}
A complex antioxidant system is present in human saliva, with uric acid being the most concentrated component. Ascorbic acid, present at low concentrations in saliva, is actively secreted into the gastric lumen. We report that ascorbic acid added to human saliva at pH 2 was consumed within a few minutes, regenerating HNO(2), whereas uric acid was consumed relatively slowly in a nitrite-dependent manner. The consumption of uric acid was (i) rapid under normoxic conditions and slower at low… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Altered uric acid levels and disease states.

The Journal of pharmacology and experimental therapeutics • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…