Salivary tau species are potential biomarkers of Alzheimer's disease.

  title={Salivary tau species are potential biomarkers of Alzheimer's disease.},
  author={Min Shi and Yu-Ting Sui and E. R. Peskind and Ge Li and Hyejin Hwang and Ivana Devic and Carmen Ginghina and John Scott Edgar and Catherine Pan and David R. Goodlett and Amy R. Furay and Luis Francisco Gonzalez-Cuyar and Jing Zhang},
  journal={Journal of Alzheimer's disease : JAD},
  volume={27 2},
Phosphorylation of tau protein is a critical event in the pathogenesis of Alzheimer's disease (AD). Increased phosphorylated tau and total tau levels, combined with reduced concentrations of amyloid-β 1-42 (Aβ42) in cerebrospinal fluid (CSF), but not in plasma or serum, have been generally accepted as sensitive AD diagnostic markers. However, obtaining CSF is a relatively invasive procedure that requires participation of specially trained medical professionals, i.e., CSF is not an ideal sample… CONTINUE READING
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