Salivary response to esophageal acid in normal subjects and patients with reflux esophagitis.

@article{Helm1987SalivaryRT,
  title={Salivary response to esophageal acid in normal subjects and patients with reflux esophagitis.},
  author={James F. Helm and W Jean Dodds and Walter J. Hogan},
  journal={Gastroenterology},
  year={1987},
  volume={93 6},
  pages={
          1393-7
        }
}
We studied the effect of esophageal acid perfusion on salivation in patients with reflux esophagitis and in normal subjects. Serial 10-min saliva collections were obtained by expectoration during perfusion of the esophagus with water, and then 0.1 N HCl (pH 1.2) for 50 min or 0.01 N HCl (pH 2.1) for 120 min. Within 1-5 min of beginning 0.1 N HCl perfusion, all 8 patients with esophagitis developed heartburn accompanied by an increase in saliva flow. By the time the severity of heartburn… CONTINUE READING

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