Salivary gland cancers: biology and molecular targets for therapy.

  title={Salivary gland cancers: biology and molecular targets for therapy.},
  author={Diana Bell and Ehab Y Hanna},
  journal={Current oncology reports},
  volume={14 2},
Salivary gland carcinomas are a heterogeneous group of tumors with different biologic behavior. Given the lack of large randomized studies, there is no standard treatment for advanced and/or metastatic salivary gland tumors, and systemic therapy is empirically based. Tumor-specific recurrent chromosomal translocations and fusion oncogenes in aggressive head and neck malignancies have diagnostic, therapeutic, and prognostic implications. Pathognomonic fusion transcripts have been identified in… CONTINUE READING