Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.


OBJECTIVES The objective of this study was to identify systemic diseases associated with hyposalivation and xerostomia and develop evidence-based management recommendations for hyposalivation/xerostomia. STUDY DESIGN Literature searches covered the English language medical literature from 1966 to 2005. An evidence-based review process was applied to management studies published from 2002 to 2005. RESULTS Several systemic diseases were identified. From studies published 2002 to 2005, 15 were identified as high-quality studies and were used to support management recommendations: pilocarpine and cevimeline are recommended for treating hyposalivation and xerostomia in primary and secondary Sjögren's syndrome (SS). IFN-alpha lozenges may enhance saliva flow in primary SS patients. Anti-TNF-alpha agents, such as infliximab or etanercept, are not recommended to treat hyposalivation in SS. Dehydroepiandrosterone is not recommended to relieve hyposalivation or xerostomia in primary SS. There was not enough evidence to support any recommendations for the use of local stimulants, lubricants, and protectants for hyposalivation/xerostomia. However, professional judgment and patient preferences may support the use of a specific product for an individual patient. CONCLUSIONS These evidence-based management recommendations should guide the clinician's management decisions for patients with salivary dysfunction related to systemic disease. Future treatment strategies may include new formulations of existing drugs, e.g., local application of pilocarpine. Recent discoveries on gene expression and a better understanding of the etiopathogenesis of SS may open new treatment options in the future.

Citations per Year

408 Citations

Semantic Scholar estimates that this publication has 408 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Bltzingslwen2007SalivaryDA, title={Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.}, author={Inger von B{\"{u}ltzingsl{\"{o}wen and Thomas P . Sollecito and Philip C. Fox and Troy E. Daniels and Roland Jonsson and Peter B . Lockhart and David Wray and Michael T. Brennan and Marco Carrozzo and Beatrice Gandera and Takashi Fujibayashi and Mahvash Navazesh and Nelson L. Rhodus and Morten Schi\odt}, journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics}, year={2007}, volume={103 Suppl}, pages={S57.e1-15} }