Salivary cortisol, APOE-ε4 allele and cognitive decline in a prospective study of older persons

@article{Gerritsen2011SalivaryCA,
  title={Salivary cortisol, APOE-ε4 allele and cognitive decline in a prospective study of older persons},
  author={Lotte Gerritsen and Hannie C Comijs and Dorly J H Deeg and Brenda W Penninx and Mirjam I Geerlings},
  journal={Neurobiology of Aging},
  year={2011},
  volume={32},
  pages={1615-1625}
}
OBJECTIVE We determined whether salivary cortisol levels were associated with cognitive decline at follow-up in older persons and whether this association was modified by the APOE-ε4 allele. METHODS Within the Longitudinal Aging Study Amsterdam (LASA), a population-based prospective cohort study, 911 persons (74.5±7.2 years, 46.4% male) collected salivary cortisol in the morning and late in the evening. At baseline and after 4 years of follow-up, global cognitive functioning, verbal memory… CONTINUE READING

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